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Huibin Weng, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Clinical studies demonstrate that GHK-Cu: Improves skin elasticity Reduces fine lines in some cosmetic studies Increases dermal thickness Enhances wound healing in limited models However: Most trials are small Many are cosmetic rather than mechanistic Long-term systemic data are limited Claims regarding hair regrowth and systemic anti aging effects exceed what controlled human trials demonstrate

Moreover, GSH levels and GSH to GSSG ratios can vary across mouse strains 52 , and therefore could also affect cysteine supply to tissues (and tumours) in these mice

PMID: 153 LiuJChiangHCXiongWLaurentVGriffithsSCDlferJet al