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mechanistic validation demonstrated that microbially derived butyrate alleviates hypoxic intestinal injury by inhibiting lactate accumulation and overactivation of HIF-1 (Zhao et al., 2024)

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For example, one study revealed that an overexpression of GPX1 inhibited the nucleus-translocation of apoptosis-inducing factor (AIF) from mitochondria in neuronal cells after ischemia-induced apoptosis (Zemlyak et al., 2009), another analysis showed that GPX1 decreased the ratio of Bax:Bcl-2 to create a more antiapoptotic environment in human endothelial cells (Faucher et al., 2005)

doi: 10.1038/cmi.2017.88 27 GleesonLESheedyFJPalsson-McDermottEMTrigliaDOLearySMOSullivanMPet al