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For a more functional assessment, markers like methylmalonic acid (MMA) can be helpful, as they rise when B12 is functionally deficient even if serum levels are borderline

Bennett and Madden, 2014

In our study, environmental inflammatory factors including IL-1 were significantly increased in mice subjected to social isolation stress, which is in line with previous studies that indicated that people who experience adversity early in their lives have a significant increase in CRP and IL-6 levels compared to healthy individuals 43

Pre-erythrocytic activity of M5717 in monotherapy and combination in preclinical Plasmodium infection models