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Reference: Hsieh et al., 2017 (VEGFR2AkteNOS signalling involvement) VEGFR2 activation triggers: VEGF binding VEGFR2 autophosphorylation (turns on VEGFR2) which leads to PI3K activation which leads to Akt phosphorylation Akt (Protein Kinase B) is critical because it phosphorylates (turns on) eNOS which leads to Nitric oxide synthesis more nitric oxide

Researchers reading their syringes in units convert the target milligram dose into the corresponding unit mark based on this concentration relationship

The treatment increased skin density and thickness, reduced fine lines and the depth of wrinkles, reduced photodamage and hyperpigmentation, improved skin clarity, and increased keratinocyte proliferation

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