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Morphine is then glucuronidated by a phase II reaction via UDP-glucuronosyltransferase (UGT) to morphine-3-glucuronide (M3G) (Fig

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Functionality of these synapses was confirmed by the presence of analog-induced spino genesis and colocalization of synaptic markers in newly formed dendritic spines, coupled with the recording of enhanced miniature excitatory postsynaptic currents