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Research Square PrintSeptember 15th, 2022

The monoamine hypothesis describes that depression is resulted from the abnormal transmission of monoamine neurotransmitters, including synaptic deprivation of monoamine neurotransmitters, and dysfunctions of monoamine transporter and receptors ( 2.2 Glutamatergic hypothesis and GABAergic deficit hypothesis Glutamate is an excitatory amino acid that plays an essential role in cognitive functions such as learning and memory