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Moreover, in another study, L-theanine effectively regulated the secretion of cytokines such as IFN-, IL-2, IL-4, IL-10, IL-12, and TNF- except for IL-6 by activating the mRNA and protein expression of Ras-related protein Rap-1A (Rap1A), 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), and farnesyl diphosphate synthase (FDPs) in the mevalonate synthesis pathway of rat splenic lymphocytes (93)

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10.1016/0731-7085(89)80084-6 141 TanakaS.YasudaT.HamadaY.KawaguchiN.FujishitaY.MoriS.et al (2020)