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Sci Rep 15 , 22157 (2025)

LDs store PUFAs, which are highly susceptible to oxidation

Liver fibrosis was induced in Lrat-Cre and Ets1-floxed mice by oral administration of carbon tetrachloride (CCl 4 ) for 6 weeks, followed by regression of liver fibrosis for 2 weeks

These cascading events require co-regulation of the multifarious cellular signaling pathways such as JAK2/STAT3 pathway, TLR2/4 pathway, Receptor for Advanced Glycation End products/mammalian target of rapamycin signaling (RAGE/mTOR) pathway, Phosphatidylinositol 3-kinase/Protein Kinase B (PI3K/AKT) pathway, Plant Inositol Phosphate Kinase (PIPK1/PIPK3) pathway, Silent information regulator of transcription 1/Nuclear factor erythroid 2-related factor 2/Nuclear factor kappa B (SIRT1/Nrf2/NF-B) pathway (Wu et al., 2009