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The CTH@MN system (CeO 2 @Tau@Hydrogel@Microneedle) leverages taurines anti-senescence properties and cerium oxides potent mtROS-scavenging ability to inhibit the ROS/NF-B pathway and activate autophagy (Table 2)

Baicalin, a flavonoid metabolite extracted from the roots of Scutellaria baicalensis Georgi [Lamiaceae], suppresses the MicroRNA-205/NF-B axis, attenuating inflammation and apoptosis (Yang et al., 2021b

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However, the products of the Fenton reaction can also damage cells, through DNA or protein repair mechanisms, this can be reduced by removing or synthesizing new substances to replace the damaged cellular components