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Subcutaneous injections exceeding 0.5mL per site reduce absorption efficiency due to depot formation, which is why protocols exceeding 125mg daily should split doses across multiple injection sites or use oral administration instead

Full-length growth hormone produces fat loss but also elevates IGF-1 (with implications for cell proliferation and aging), worsens insulin sensitivity and elevates blood glucose (problematic for diabetics and pre-diabetics), promotes muscle growth and protein synthesis (which may be desired or unwanted depending on goals), causes fluid retention and edema in many users, and requires careful medical monitoring with regular blood work

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doi: 10.1002/path.1693