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Conjugation with HMCDs could be a logical approach to increase the tumor specificity and bioavailability in brain tumors, whilst reducing the doses required to overcome liver degradation and minimize toxicity

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The high heterogeneity of HNSCC, including differences in HPV status, primary tumor sites, driver gene mutation profiles, and tumor microenvironment heterogeneity, leads to significant inter-individual variations in treatment response, making the traditional one-size-fits-all therapeutic model ineffective