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Funding This study was financed in part by the Coordenao de Aperfeioamento de Pessoal de Nvel SuperiorCAPES (finance Code 001) and by the Postgraduate Program in Nutrition of the Federal University of Santa Catarina, Brazil

Another advantage of this method is that the amide linkages formed by this technique (as well as those created by the NHS method) are more stable than the isourea linkages obtained by CNBr immobilization