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Antimicrobial topological surface have been explored for years, but it functions mainly in the early adhesion stage and the underlying mechanisms are still unclear and the diverse effects of topographies such as micropillars, rows and concaves, especially at the nanoscale, need to be explored further ( While local drug injections and ultrasound therapy are still commonly used to combat implant infections, these alone are not sufficient to deal with recalcitrant drug-resistant bacteria, and surgical debridement is often ineluctable eventually

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