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Description

51V NMR crystallography of vanadium chloroperoxidase and its directed evolution P395D/L241V/T343A mutant: protonation environments of the active site

Olaparib, a PARP inhibitor (PARPi), has been demonstrated to not only exacerbate cellular senescence by amplifying DNA damage, upregulating senescence markers (e.g., SA--gal and p21), and inducing irreversible cell cycle arrest, particularly in replicatively senescent macrophages but also trigger mixed apoptotic and necrotic cell death at high doses