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Variants of this gene are also involved in medication resistance to antiviral and anticancer drugs.[ref] The wet earwax allele was also associated with a higher risk of breast cancer in Japanese women but not in women of European descent.[ref][ref][ref] In Japanese men, carrying the allele associated with wet earwax is linked with an increased risk of hidradenitis suppurativa .[ref] Hidradenitis suppurativa is a painful skin condition causing pus-filled lumps under the skin, usually in the underarms, buttocks, or groin areas

This approach aims to restore normal mitochondrial function in diseased cells, although it remains largely experimental ( 8.2 Nutritional strategies Nutritional strategies aimed at improving mitochondrial function are increasingly recognized as potential complementary therapies for managing inflammatory lung diseases