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Although a trimodal ageatonset distribution has been proposed, this disease has typically its onset between adolescence and early adulthood [2]

Parag Mallick, chief scientist at Nautilus Biotechnology, says he thinks the field is understanding now more than ever that tau is not a single protein that goes up and down. For example, in a single-molecule study that Mallick and his team posted to bioRxiv, researchers identified at least 130 different tau proteoforms in brain organoids and donor tissue

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