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In saliva, but not in serum, various polyphenols, and the microbial metabolite 5-(3,4-dihydroxyphenyl)--valerolactone were exclusively present as unconjugated molecules ( 6.3 Site-specific metabolism: blood cells The observation of a facilitated uptake of 5-(3,4-dihydroxyphenyl)--valerolactone into blood cells and its determination in cell samples of osteoarthritis patients after intake of Pycnogenol (see section 5.2 Distribution into blood cells) prompted systematic advances to elucidate the detailed metabolism of 5-(3,4-dihydroxyphenyl)--valerolactone in human blood cells ( ( 7 Elimination The major excretion routes of dietary polyphenols and their metabolites include renal and biliary elimination of compounds circulating in blood

These findings indicate that both the overexpression of GSTe4 and allelic variations significantly impact resistance to DDT

FEBS Leters 436, 7175.Google Scholar Day, AJ & Williamson, G (2001) Biomarkers for exposure to dietary flavonoids: a review of the current evidence for identification of quercetin glycosides in plasma