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The NaOH concentration also affected the surface area and average pore diameter of Se/PPS-I, in which a higher NaOH concentration created a lower surface area and higher average pore diameter due to the formation of a dense selenium layer

Under some pathophysiological circumstances, endothelium-derived vasoconstricting factors, such as ET-1, AT-II, urotensin II, superoxide anions, vasoconstrictor prostaglandins and thromboxane A 2 , can be released and contribute to the paradoxical vasoconstrictor effects

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