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S100A15 protein is predictively composed of 101/104 amino acid residues, in which 13-48 residues contain the N-terminal non-canonical EF-hand domain, and 50-85 residues contain the canonical C-terminal EF-hand motif (168) ( Figure 1 )

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The methodologic design of the rescue arm favors the sq methotrexate group, in that, on average, approximately 10% of the subjects in this group received a 25% higher dose of methotrexate than did those in the oral group (who could never receive a dose higher than 15 mg as part of the protocol)