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Besides eGFR, additional variables associated with kidney function including plasma urea 29 , the uremic toxin p -cresol 30 or markers of kidney function decline (i.e., serum albumin 29 ), were among those affecting model outcomes the most

Patients can expect to see a reduction in pain and inflammation, followed by noticeable improvements in bone recovery within the first few days or weeks

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Preliminary findings from these studies suggest a tolerable oral dosage of approximately 100mg/kg in mice [1]