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Differences in results are due to a combination of factors including ascorbic acid-related concerns (doses, administration routes, plasmatic levels, metabolites recording, and source), cancer characteristics (specific mutations present, type and grade of cancer, received conventional anti-cancer therapy), and individual characteristics (diet, behaviors, genetics, transporters)

Significantly, an unfavorable EBV DNA response after induction chemotherapy or at the midpoint of RT is also shown to be an adverse prognosticator for clinical outcome