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However, causal associations remain unproven in humans, and major methodological challenges persist, including inconsistent detection methods, limited epidemiological data and inadequate modelling of real-world exposure

It is worth mentioning that the family Ruminococcaceae possesses inflammatory attributes, producing polysaccharides like glucomannan, which have the capability to prime immune cells [171, 175]

In NK cells, the upregulation of SLC1A5 expression drives the production of IFN- factors, thereby enhancing antitumor and immune surveillance effects [39]