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Factors responsible for the induction of ferroptosis may directly or indirectly affect glutathione peroxidases

doi: 10.1152/ajpcell.1992.263.6.C1181

Hepatocyte cytotoxicity significantly increased with ITZ concentration ( P 30 metabolites in humans (31)

Avoid temptation increasing dose or frequency thinking "more is better." Stable effective protocol through completion then reassess need for continued treatment versus tapering