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Figure 5 Downstream cellular mediators of Dihexa protection Activation of the receptor tyrosine kinase c-Met leads to the recruitment of many signaling mediators and ultimately the activation of downstream signals, most notably Akt-TOR and Ras-ERK (Organ and Tsao, 6A)

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Keywords: Telomerase, ALT, Telomere length, Mammalian cells Introduction The average age of the worlds population is increasing year on year due to people living longer and a decline in the birth rate (Beard et al 2016)