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By using brainstem-specific spatial registration in addition to standard neocortex spatial registration, neuroimaging studies of ME/CFS are much more likely to detect any functional and structural abnormalities that may be driving autonomic and neuroimmune-related symptoms

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In the future, researchers should develop Mn 2+ sensors that target specific organelles to elucidate the dynamic changes and physiological roles of intracellular Mn in different cellular compartments

According to this model, the massive oxidative stress of the initial infection not only depletes glutathione but also partially blocks the body's methylation cycle and folate metabolism