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Research published in Cell Metabolism demonstrates that GIP receptor activation enhances nutrient partitioning, meaning the body becomes more efficient at directing calories toward metabolically active tissue rather than fat stores

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Shaw K, Williams SP, Patrick M, ValenciaPrado M, Durkin MS, Howerton EM, Ladd-Acosta CM, Pas ET, Bakian AV, Bartholomew P, Nieves-Muoz N, Sidwell K, Alford A, Bilder DA, DiRienzo M, Fitzgerald RT, Furnier SM, Hudson A, Pokoski OM, Shea L, Tinker SC, Warren Z, Zahorodny W, Agosto-Rosa H, Anbar J, Chvez K, Esler A, Forkner A, Grzybowski A, Agib AH, Hallas L, Lopez M, Magaa S, Nguyen RHN, Parker J, Pierce K, Protho T, Torres H, Vanegas SB, Vehorn A, Zhang M, Andrews J, Greer FL, HallLande J, McArthur D, Mitamura M, Montes A, Pettygrove S, Shenouda J, Skowyra C, Washington A, Maenner MJ (2025) Prevalence and early identification of autism spectrum disorder among children aged 4 and 8 yearsautism and developmental disabilities monitoring network, 16 sites, United States, 2022

However, its effectiveness appears to be more pronounced in injected forms for gastrointestinal conditions 4