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Beneficial effects of quercetin on vincristineinduced liver injury in rats: modulating the levels of Nrf2/HO1, NFkB/STAT3, and SIRT1/PGC1

If a reactive intermediate is produced faster than glutathione and other Phase II systems can neutralize it, oxidative stress and liver injury may increase

Lyons KE, Wilkinson SB, Trster AI, Pahwa R (2002)

Moreover, research shows that selenium-dependent GPx enzymes, or seleno-GPxs, have synthetic mimics being developed, mainly organoselenium compounds, to replicate their protective effects in therapeutic applications