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Akasaka et al

focused on changes in weight, hirsutism scores, menstrual cycles, endocrine-metabolic profiles, and other factors in adolescent patients with PCOS with low birth weight (LBW) and precocious pubarche (PP) who received metformin treatment at different stages

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People with a compromised immune system If you have a weakened immune system whether its because of chemotherapy, organ transplantation, biologics or HIV you face a double challenge: Not only are you more vulnerable to severe illness if you get the flu, but your immune response to the vaccine may be blunted