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In summary, the implication of IGF-1 in glucose and lipid metabolism and its derangements when the GH/insulin/IGF-1 axis balance fails is well documented

When evaluating adipose tissue in WT and 3-KO mice, researchers found that neither treatment significantly affected white adipose tissue mass in either genotype

But elevated TGF-beta-1 means follicles exit anagen sooner than they should, resulting in shorter growth cycles, shorter strands, and over time, reduced hair density