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A phase 2 clinical trial published in the New England Journal of Medicine (2023) demonstrated significant body weight reductions in participants with obesity, generating considerable scientific interest

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doi:10.1111/ejn.13741 [doi] Villanueva-Millan MJ, Leite G, Morales W, Sanchez M, Parodi G, Weitsman S, Celly S, Cohrs D, Do H, Barlow GM, Mathur R, Rezaie A, Pimentel M., Hydrogen Sulfide Producers Drive a Diarrhea-Like Phenotype and a Methane Producer Drives a Constipation-Like Phenotype in Animal Models., Dig Dis Sci

This dramatic attrition underscores not only methodological deficits, such as inadequate randomization, absence of blinding, and insufficient statistical power, but also systemic issues in model validity and disease representation