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The above-reported evidence suggests that, on the basis of the initial localization of pathological forms of -syn, different subtypes of PD can be identified in addition to the traditional staging framework based on the canonical Braak pattern, which is characterized by the caudo-rostral spread of -syn-positive LBs, which originate in the brainstem and systematically ascends toward the neocortex [101, 102]

10.1016/j.jep.2009.04.005 87

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This defect results in imbalance in the /-globin chain ratio, ineffective erythropoiesis, chronic hemolytic anemia, and iron overload