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In several animal models, such as hypoxia and ischemia, the conclusion is that the hippocampus is the most vulnerable brain region to oxidative damage and degeneration due to the over-activation of glutamate receptors, activation of caspases, and subsequent cell death (Figure 17) might be responsible for the impairment in memory and learning exhibited by the rats in Group II and the protective effect of DMSO may perhaps be responsible for the enhancement of learning and memory observed in Group I

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