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These molecular alterations converge to impair cognitive performance, suggesting a mechanistic link between anesthetic exposure, neuroinflammation, and synaptic dysfunction (Faraco et al

Influence of Tozasertib on oxidative dysfunction In the present study, ICV STZ treatment led to an increase in oxidative stress, evidenced by a significant rise in thiobarbituric acid reactive substances (TBARS) levels, and a decrease in glutathione (GSH), superoxide dismutase (SOD), and catalase levels, compared to the vehicle group (Fig