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The proteomic results suggested that the immunoproteasome subunit 5i was decreased in livers from ibuprofen treated male mice and Western blotting and proteasome assays suggest gender-specific differences with respect to proteasome and immunoproteasome activities

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Future studies leveraging the genetic tractability of Drosophila could further dissect the molecular pathways influenced by such natural compounds, accelerating the discovery of novel AD therapeutics