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Cautions with N-Acetylcysteine (NAC) supplements: Increasing NAC and glutathione could be detrimental if you are undergoing therapy for certain types of cancer because some tumor cells thrive with more glutathione.[ref] Always talk with your doctor if you are undergoing treatment or have medical questions

Second, the efficiency of endogenous antioxidant systems decreases with age, a core feature of which is the reduction in the levels of the master intracellular antioxidant, GSH (103,104)

Calorie restriction and aging: review of the literature and implications for studies in humans

In clinical practice, IRI can lead to severe AKI and delayed functional recovery after organ transplantation [141]