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Supplement & Nutritional Therapy Supplements to prevent muscle cramps with the best evidence include: Magnesium glycinate or citrate most effective for nocturnal leg cramps, toe cramps, and whole-body spasms related to electrolyte imbalance Potassium particularly valuable for leg cramps at night and charley horses in athletes Vitamin D3 + K2 addresses deficiency-related myofascial pain and muscle weakness Vitamin B12 important for nerve health

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Orphanet journal of rare diseases, 17(1), 310

48 However, double deletion of ZO-1 and ZO-2 established leaky monolayers with the complete loss of TJ strands, 45 suggesting that ZO-1 and ZO-2 have overlapping functions in anchoring the TJ strand