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Additionally, maspin expression enhances the sensitivity of PCa to salinomycin, induces redifferentiation of PCa tumors, and inhibits bone matrix remodeling and angiogenesis, thereby preventing bone metastasis of PCa [120]

Unlike the well-established link between increased OS and diabetes in humans, which is associated with dysfunctional mitochondria and glucose auto-oxidation [3,111], studies in dogs have produced variable results