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Analysis of p21-positive cells was consistent with increased senescence on cisplatin treatment and a significant reduction on combination treatment (Fig

#1610747, Bio-Rad) for 5 min

DIETARY REGULATORS OF GSTP1 EXPRESSION Since progressive GSTP1 hypermethylation is a hallmark biomarker but potentially also a driver of prostate cancer progression, various research teams were looking for dietary intervention to lower the methylation burden of GSTP1 gene promoter

Results: In the CCl 4 mouse model of HE and in human autopsy samples, markers of senescence and SASPs were observed, specifically in neurons of the CA1 and dentate gyrus in the hippocampus and in the Purkinje cell layer in the cerebellum, regions known for learning, memory and motor control