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The efficiency of naked plasmid DNA transfection is very low, but the target cells can be transduced by adeno-associated virus, retrovirus, and non-viral vector system

Feng et al., 2019)

From a genetic background perspective, TP53 mutation status significantly affects ferroptosis sensitivity by regulating the TP63/GPX4 axis, whereas CDKN2A deletion increases ferroptosis susceptibility by altering the lipid compartment distribution of PUFAs ( The spatiotemporal heterogeneity of the TIME further increases treatment complexity