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That lineage process has been extensively characterized by numerous investigators with characterization of the cells in the periportal (zone 1) versus midacinar region (zone 2) versus pericentral (zone 3) zones and the final stage, the Axin2 + diploid cells, mediating clearance of apoptotic cells

Ichi S, Nakazaki H, Boshnjaku V, Singh RM, Mania-Farnell B, Xi G et al (2012) Fetal neural tube stem cells from Pax3 mutant mice proliferate, differentiate, and form synaptic connections when stimulated with folic acid

The absence of plant-derived cofactors in synthetic preparations may limit synergistic antioxidant effects, but it also allows for standardized dosing and cleaner pharmacokinetic profiling, which are critical advantages for clinical application