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Moreover, GSNO at this concentration was non-toxic to HUVECs, the first cells exposed to GSNO-derived NO during retrograde perfusion, supporting its safety and endothelial tolerance in this experimental setting

Naunyn-Schmiedeberg's Arch Pharmacol 399 , 1465914676 (2026)

Its tolerance to 10% NaCl and quaternary ammonium disinfectants enhances its persistence in healthcare settings ( Supplementary File 1 )

Fibrosis is caused mainly by the overactivation of cardiac fibroblasts, which results in the production of excessive extracellular matrix (ECM) components