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These organs communicate through various signaling pathways and factors, including adipokines, myokines, cytokines, hormones, and exosomes, mutually influencing each others functions and contributing to systemic metabolic dysfunction (Fig

However, our understanding of the regulatory mechanisms both within and between the Asc synthesis pathways remains limited

In addition, the involvement of active oxygen species as secondary messengers for toxicity was investigated [346] and the prevention of such toxicity by scavengers of active oxygen species was also presented [347]

doi: 10.1016/j.ijid.2021.02.107 2 SinghRDwivediSPGaharwarUSMeenaRRajamaniPPrasadT