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Specifically, RT-induced ROS can promote the release of tumor-associated antigens (TAAs), regulate the infiltration and differentiation of immune cells, manipulate the expression of immune checkpoints, and change the tumor immune microenvironment (TME)

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Considering that current anti-inflammatory therapy (steroids and immunosuppressant drugs) remains unsatisfactory due to substantial side effects and uncontrolled relapses (349), understand the interaction between gut microbiota and IEB, particularly at the early subclinical phase of inflammatory disease, could be used to identify novel therapeutic approaches in chronic intestinal inflammation

The cellular level concentration of GSH is maintained by glutathione reductase (GR) [39], which reduces GSSG to GSH by using NADPH as cofactor