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This cross-reactivity means metabolic effects (including hypoglycemia at higher doses) are possible in research models and should be monitored in in vivo protocols

In contrast to our in vitro results, treatment with MitoQ, DPI, or their combination did not produce notable effects on tumor size reduction, even at the highest tolerable doses ( Figure 9A )

Whether that direct-delivery advantage shows up in tissue levels is the open question above, but in his view its the reason he switched

We try to strike a balance between pushing detoxification enough to get results, without backfiring into side effects and negative symptoms