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The synergistic effect of nutritional-related metabolic syndrome on OA Beyond obesity alone, the constellation of nutrition-related metabolic syndrome (MetS) components including insulin resistance, dyslipidemia, and hyperglycemia, synergistically exacerbates OA progression through interconnected pathways

The identification of significant CAZymes in the AGAu cluster showed carbohydrate conversion of xylan (GH43_8), mucin (GH95), cellulose (GH66) and copper oxidase family (AA5) 72,73,74

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