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Activation of caspase-1 by inflammasomes induces pyroptosis, an inflammatory form of programmed cell death (Wroska et al., 2024)

5.1.1 M1 macrophages Upon encountering allergens or pollutants, macrophages often polarize toward a pro-inflammatory M1 phenotype

Characterized by lipid peroxidation and abnormal iron accumulation, ferroptosis has attracted significant attention due to its unique association with pathological conditions such as ischemia-reperfusion injury, neurodegeneration, and cancer [2,3,4]