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Rather than inducing desensitization, a chronic morphine treatment could promote a compensatory increase in intracellular cAMP level (also named cAMP overshoot or ACase superactivation) (Avidor-Reiss et al., 2009)

Future research might explore the use of nicotinamide in combined therapy and evaluate activators of NAD-dependent enzymes

Acknowledgements NM is thankful to University Grants Commission (UGC), New Delhi, India for providing Senior Research Fellowship [F.No.16-6(DEC.2018)/2019(NET/CSIR)]