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The latest study by the same group suggests that this effect may result from Mn impairing lysosomal protein degradation (Rokad et al., 2024)

For instance, IPA specifically binds to methionine adenosyltransferase 2A (MAT2A), enhancing S-adenosylmethionine synthesis and subsequently inducing DNA methylation of the deubiquitinating enzyme USP16

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The review also delves into an examination of various nutritional antioxidants, namely vitamin C, vitamin E, carotenoids, selenium, zinc, polyphenols, coenzyme Q10, and probiotics, and elucidates their role in mitigating the adverse effects of oxidative stress arising from imbalances in adrenal hormone levels