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PAMPs from persistent pathogen components and DAMPs from mitochondrial stress synergistically activate the NLRP3 inflammasome and NF-B pathway, which are the core innate immune pathways mediating the conversion of metabolic stress into systemic inflammation

Grosjean D, Swanson RD, & Ellis C (1983) Carbonyls in Los Angeles air: Contribution of direct emissions and photochemistry

Psychiatry 27 , 13501361 (2022)

Shaking introduces significant mechanical stress that can break the delicate chemical bonds holding the peptide chain in its specific, functional shape