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Our results demonstrated that LPS- exposure induced the inflammatory response, including cytokine expression (IL6, IL-1, TNF) in macrophages, along with Trp-catabolic enzymes IDO1 and associated catabolites Kyn levels in both THP1 and primary KCs

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By inhibiting the signaling axis of the P2X7 receptor and the NLRP3 inflammasome, colchicine can terminate the inflammatory response at the intracellular level